THE GREATEST GUIDE TO METHADONE KIDNEYS

[61] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with unique potency. Dextromethadone, which happens to be considerably less powerful as an opioid, is much more powerful at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone provides a lower affinit